Here Bernstein discusses how a large dose greatly extends the action time. A non-diabetic volunteer received 70 units of regular insulin in one site and had to receive IV glucose for an entire week to avoid hypoglycemia. http://www.diabetes-book.com/laws-small-numbers/ The effusion rate law suggests that effusion of a subcutaneous injection will be absorbed on a percentage basis in proportion to the inverse square or cube of the injection amount (depending on whether it is 2d or 3d effusion). that would mean that if a 10 unit injection effuses over 6 hours a 1 unit injection would effuse in 30-45% of the time (less than 2 to 3 hours) as a 10 unit dose, although some of the lag time is in reaching and becoming active in the liver. Whatever the case may be, I believe that the entire action curve for a small dose is dilated compared to a standard dose. You guys have access to dexcom to verify that your kids aren't going low though, and that is what I need.