Another huge problem that has not been mentioned yet in this thread is the inherent absorption issues with inhaled insulin. The insulin has to pass through various orifices in the body and also mucous membranes, which will lead to large variations of absorption, no matter the consistency of the inhalation technique used and no matter how well the inhaler is designed to reduce this risk. By the way, I have a very complicated medical situation, and I have medical conditions not related to my diabetes that compromise my control a lot. Because I am desperate for being as "healthy" as possible and for having decent control, I am strongly considering this option, even with the risks, such as decreases in lung functioning. In my very personal opinion, inhaled insulin has "bad idea" written all over it, but I am still desperate to try something to improve my overall health and functioning. Desperation can definitely cause a person to make bad decisions with serious consequences. I don't want to be one of them, so I guess I need to keep things in perspective, and not be a "guinea pig" and just wait awhile. Anyways, I am more of a fan of technological innovation, rather than pure biological or pharmaceutical innovation anyways. I strongly believe that a predominately technological cure has more potential of curing diabetes than a pure biological one, because eventually technology will likely allow us to supersede our biological limits. From that respect, I do believe BioMEMS is potentially the most likely way type 1 is going to be cured (although not technologically possible at this time) through the encapsulation of islet cells. Do not ask me how the encapsulation will be possible, but I am convinced that a diabetes cure is technologically possible with BioMEMS, around 20-30 years from now (when it is expected to be theoretically prevalent and possible).