I'd like to clarify what I mean by "diagnosis" - Positive TTG and EMA antibodies is sufficient for diagnosis of autoimmune gluten sensitivity, AKA celiac. A biopsy IS requried to confirm that celiac is actually causing damage to the GI tract. A positive biopsy confirms celiac. A negative biopsy means you have latent celiac disease. Latent celiac disease has been proven to cause health damage if gluten continues to be consumed, even if the annual biopsy continues to be negative (see article I posted above). Celiac is an elevated-antibody condition that affects much more than just the GI tract. So it really depends what you are tring to diagnose: Celiac, or GI damage which is just one of many possible health effects of celiac.