I recently posted a thread seeking help with overnight basals. I was experiencing significant difficulty with Caleb's BGs bt 8 and midnight. He would experience significant highs, I would correct, but they would sustain. I would gradually bump up his basals, finally get good numbers and then have a series of nights of lows. And then the cycle would start all over again. I had started to attribute the problem to growth hormone making his BGs unpredictable. However, I have concluded that the issue was less his basal than I thought. Since I have changed his correction factor during this period, the "swings" are less dramatic. This is still the most difficult period of the day for me, but it it far better since I adjusted the correction factor. I had thought that since his correction factor worked perfectly during the day, the fact that a slightly different one wasn't working at night was because his basals were terrible off, so I would erroneously increase the basals which eventually resulted in the lows. I'm also always nervous about making increases at night bc he does not wake up to lows - the thought of increasing his CF during this time by so much was a little terrifying. But when I finally took the plunge and made a big change in the CF, it worked. His day CF is 250. His CF for this nighttime period is 155 (I had been using 200 - 220 during this time which wasn't enough). His basal needs for this night time period are also the most significant. So although growth hormone likely results in variation in BGs during this period, that was not the whole story. I just wanted to share for anyone else who might have a similar situation. It seems pretty obvious to me now that the correction factor should be significantly different during periods of significantly different basals, so perhaps it's obvious to everyone else, but I just wasn't getting that at the time.