We've always had problems figuring out the night time basal/bolus from before we started pumping. While the daytime readings are goodish, at night the sugars start out normal after the meal, and would often suddenly shoot up about 3-4 hours after the meal (200+). So we just got used to testing frequently at night, correcting and changing basals every few months. Works sometimes, but I can't remember when I wasn't testing at night. Things have got really bad recently. I kept getting 300+ readings around 1:30 am and thought at first it might be a low rebound, specially because the correction (of 2+ units) would not seem to have much impact. I even thought it may be a quickset problem (we've had problems of bent canulas in the past) and changed the quickset on at least 3-4 occasions. Finger tests showed the same normal readings one hour after the meal, spiking late at night. She's not usually on a sensor but when we did the CGMS, it didn't show up a low. It did show that sugars dropped to 110-120 about an hour after the meal at night and then crept up slowly about 3 hours after the meal (still normal). She has about 60 odd carbs, vegetables and protein and there's not much fat at all in the meal; she takes a dual wave since much of the carbs are also relatively slow acting. It's got worse in the last week. She usually has 60-70% in-range sugars (the range is pretty broad - 70-180) but the last week has just about been 50%. No lows. Doesn't happen usually unless she's ill or had been cheating on her food (not true right now). Now the finger tests 1 hour after the meal, show the glucose at about 120-140. 1 hour later, it's usually going up - 160-180. Even after a correction, this doesn't come down and by 2:30 is 300+. Her daytime readings are pretty normal except for when she's very sedentary. Basals at night are already 50% more than the average day-time basal, so I'm reluctant to increase it very sharply from here. She turns 12 next month and just had her first period, so I was wondering if puberty had something to do with it, or if I'm just missing a low somewhere?