DS has super sensitive skin. He has a hard time with IV 3000, Tegaderm and lots of other creams, adhesives etc. He has had no problem at all with Hypafix. It has been fabulous and incredibly durable! All summer long he's worn a patch of Hypafix over his Sure-T with a little triangle cut out to cover the detachment point. It has kept his site secure through days of swimming in pools and at the beach. HIGHLY recommend it!