Did anyone attend? http://viacyte.com/press-releases/viacyte-to-present-at-isscr-2016-annual-meeting/ The ISSCR is a conference on Stem Cell research held last week. There were 10 or more posters that contained the word diabetes indicating that lots of stem cell research is ongoing within the field. The language in the posters is highly technical/scientific so I am unable to summarize other than to say work is in progress. The Viacyte research gives me hope and one researcher from that team participated in a session. All Abstracts (600+ pages): http://www.isscr.org/docs/default-source/2016-books/isscr-2016-poster-abstract-book.pdf Viacyte abstract: T2190 IN VITRO GENERATION OF INSULINPRODUCING CELLS WITH INSULIN SECRETION KINETICS AND MITOCHONDRIAL RESPIRATION SIMILAR TO ADULT HUMAN ISLETS Rezania, Alireza1, Arora, Payal1, Rieck, Sebastian1, Ng, Bruce1, Asadi, Ali2, Quiskamp, Nina2 and Kieffer, Tim3, 1Janssen, Raritan, NJ, U.S., 2University of British Columbia, Vancouver, BC, Canada, 3University of British Columbia, Vancouver, BC, Canada We recently reported on the differentiation of pluripotent human stem cells into single hormonal insulin+ NKX6.1+ MAFA+ cells (stage 7 cells) that demonstrated glucose responsiveness in a static glucose challenge assay. Further evaluation using a more sensitive dynamic perifusion assay revealed sluggish insulin release kinetics in response to glucose challenge and marginal increase in insulin release after exposure to a GLP-1 mimetic peptide. Moreover, the single hormonal insulin+ cells did not show the typical calcium flux seen with adult human beta cells indicating clear functional deficiencies as compared to mature beta cells. Using a combination of RNA Seq analysis of the cells, empirical testing of various media compositions coupled with targeted small molecule screening, we generated insulin+ cells from human embryonic stem cells (hESCs) with insulin secretion kinetics and mitochondrial respiration similar to adult human islets. Newly generated insulin+ cells acquired some of the features attributed to mature beta cells, such as expression of UCN3, MAFA, GLP-1r, and GLUT1. Notably, these insulin+ cells survived within macroencapsulation devices following transplant in the subcutaneous space of immune compromised mice and yielded significantly faster production of circulating human C-peptide compared to previous reports, with significant glucose responsiveness as early as four weeks post-implant. These results show the feasibility of generating insulin-producing cells from hESCs in vitro with characteristics of mature human beta cells.