I was diagnosed with hypothyroidism in May 2010 with a TSH of 5.96 (my T4 was also low, but I do not remember the level exactly). I started on 25mcg Levothyroxine. I think that when I was retested in 2 months my TSH was around 3, so my dosage was not raised at all. I stayed on 25mcg for quite a while. In August 2011 my TSH was 7.89 and my free T4 was also low. My dosage was raised to 50mcg and in October my TSH was down to 2.5. However, when I was retested in December my TSH was back up to 5.9 and my free T4 was again barely in range, so my dosage was raised to 100mcg. It's now February and my TSH is now 6.9 and my free T4 is lower than ever. I haven't heard from the doctor yet, but I assume that my dosage will just be raised again. Meanwhile, I am being treated for depression (we don't think it is entirely due to the hypothyroidism - although of course this isn't certain, since I've been hypoT for so long). And my diabetes is crazier than ever, which my endo is partially blaming on hypothyroidism. So, is it normal that my TSH has not been in particularly good range for the almost 2 years that I've been treated for? And does anyone have a ballpark estimate of a normal Levothyroxine dosage for a 19 year old, 5ft 5 and 120lbs? And finally, is there any particular reason why a dosage increase of 50mcg would have no effect whatsoever? The best thing I can think of is that since the autoimmune attack on my thyroid is ongoing, my TSH would be even higher if I had not raised the dosage. I don't know. It's so frustrating, though. I feel like it should have worked by now.