For the last two nights straight, I have been up every 1.5 hours, every time the alarm goes off on Jayden's pump, to treat a high. It hasn't ever been crazy high...usually it's hung around 220 or so. I give insulin (we're using Apidra, so I can give it more frequently), go back to bed, high alarm goes off again, blood sugar hasn't budged. During the wee hours of this morning, I gave a Humalog injection, put Emla on her for a site change thinking it had to be the site, and went back to bed for a bit. Got up to change out the site, and when I held up the tubing, there were huge pockets of air all throughout the tubing. I have never had air bubbles in there before. That has to be what has caused this grief. I re-primed the tubing and it took extra insulin to prime due to the air bubbles. What can you do to keep the air bubbles out of the tubing? Is it a bad connection to the reservoir that allows them in the first place? How often do you check your tubing for air bubbles?