I have seen many on here who have talked about this drug. I was wondering if we need to look for any side effects. To back up a little, Em has tested positive antithyroid antibodies since dx. She just had new bloodwork on 4/14 and it shows that her antithryroglobulin Ab is 498 and range is 0-40, and Thyroid Peroxidase (TPO) Ab is 250, range 0-34. Her TSH has fluctuated high and in range. So now endo says "given the positive antibodies and the menstual irregularities the best course of action is to put her on Thyroid Medication Replacement." She is prescribing Synthroid 88 mcgs. I got this letter today after the endo was closed so I can't call til Monday. Are these things I need to really worry about? They never have really explained all this to us at all.