- advertisement -

Encapsulife Receives U.S. Patent For Living-Cell Bio-artificial Pancreas Requiring No Immune-Suppres

Discussion in 'Research' started by Ellen, May 1, 2014.

  1. Ellen

    Ellen Senior Member

    Joined:
    Oct 22, 2005
    Messages:
    8,240
    [h=1]Encapsulife Receives U.S. Patent For Living-Cell Bio-artificial Pancreas Requiring No Immune-Suppression Drugs -- Automatically Reverses Diabetes In Primate Trials Utilizing Human Islets[/h]


    WASHINGTON, May 1, 2014 /PRNewswire-iReach/ -- Encapsulife, Inc., a global leader to cure for diabetes by employing NASA-derivative technologies, today announced the United States Patent and Trademark Office (USPTO) has issued to Encapsulife, Patent US 8,673,294 -- "Immunoisolation Patch System For Cellular Transplantation." The USPTO patent applies broadly to endocrine and neurological disorders, more narrowly to pancreatic disorders (diabetes), and specifically validates the efficacy of Encapsulife/Wang's technologies to reverse diabetes automatically and biologically, without using harmful immune-suppression drugs.
    There are no known comparable technical achievements in this arena.
    See Patent 8,673,294:
    http://www.encapsulife.org/technologies/patents/USPTO_patent_8,673,294_B2.pdf
    Dr. Taylor Wang, founder of Encapsulife, made the formative scientific observations for his encapsulation technologies as an astronaut-scientist during the 1985 Shuttle Mission STS-151/Skylab 3. Dr. Wang said, "Without NASA's Shuttle, Skylab 3, and early follow-on micro-gravity research support, none of our bio-medical advances, with promise to provide enormous medical benefits to mankind, would have come to pass. And I was pleased to tell this to NASA Administrator Charles Bolden last week."
    Encapsulife President, Tom Gibson, explained the basic technology of the bio-artifical pancreas:
    - "Recent research to cure diabetes has gravitated toward pancreatic islet transplantation. But a major challenge is the diabetic's immune system, which rejects donor islet cells;
    - Wang's bio-artificial pancreas, contains thousands of encapsulated pancreatic islet cells from a donor (human, porcine, human cloned, or human stem-cell derivative), that survive and function to produce insulin automatically, when stimulated by glucose in the diabetic's blood stream -- without being rejected by the diabetic's immune system;
    - Wang's bio-artificial pancreas has proven successful as a simple sub-cutaneous implant in dogs and has been successful in primates, using human islets. No invasive transplant surgery or harmful immune-suppression drugs are used;
    - The Wang's success is attributed to novel multi-layer immunoisolation technology -- multiple microscopic barrier-capsules around the islet cells -- which are organized in special geometric shapes and implanted under the skin. This allows:
    1. Passage of glucose and nutrients INTO the capsule to sustain living pancreatic islet cells and stimulate insulin-production;
    2. Passage of insulin, back OUT across the capsule wall(s) to enable proper metabolism and reverse diabetes, while also;
    3. Blocking the body's immune cells, that would destroy the transplanted tissue islet cells." Geoffrey Mason, patent expert and CEO of FastPatentPartner commented, "It is unusual for the Patent and Trademark Office to include an efficacy statement such as the one in the new Encapsulife patent. It shows the USPTO believes the invention will work."
    Experts credit Dr. Wang's success to use of a multiple-wall capsule for immune-protection versus others' limited success with a single-wall approach. Dr. Wang said: "Successful encapsulation has multiple requirements. Using multiple layers in our capsule model, gives us additional tools to achieve success."
    Encapsulife now will begin the process for FDA human trials to provide an automatic functional cure for diabetes. Encapsulife's Gibson said, "Having filed for this patent five years ago, it is a pleasant coincidence that the patent grant arrives in-synch with Dr. Wang's 2013 successes using the patch technology to reverse diabetes in primate trails -- done in collaboration with Dr.James Markmann, Chief of Transplantation Surgery at Massachusetts General Hospital.
    "Gibson continued, "It is also an important timing note that there continues to be excellent progress in parallel with development of Wang's bio-artificial pancreas, to develop scalable sources of islets. Recent progress includes islet cloning, adult brown fat stem cell programming to create islet cells, and use of porcine islets. For transplantation and a functional cure, new islets from any of these sources, would require immune-protection -- and that technology is at hand. With all this encouraging news our development efforts will now go into high gear. We now must move urgently to get this technology into human trials and to the victims of diabetes."
    About Encapsulife [ www.encapsulife.org ]
    Encapsulife, Inc. founded in 1998, is a small, closely-held, private Delaware corporation with a substantial patent portfolio, unique and peer-reviewed research, passionate and talented leadership, and products and processes focused on encapsulating and transplanting living islet cells to reverse diabetes automatically without use of immunosuppression drugs or external mechanical devices. Dr. Wang's research has been supported by NASA, Vanderbilt University, Helmsley Trust, Ronald McDonald Children's Charities, JDRF, Evans-Gilruth Foundation, The Chauncey and Marion D. McCormick Family Foundation, New Generation Foundation and its "Squash Diabetes" Campaign, and private donors.
    Media Contact: Brett A. Shisler, Encapsulife, 212-381-0638, info@encapsulife.com
    News distributed by PR Newswire iReach: https://ireach.prnewswire.com
    SOURCE Encapsulife


    RELATED LINKS
    http://www.encapsulife.org
     
  2. sszyszkiewicz

    sszyszkiewicz Approved members

    Joined:
    Dec 24, 2013
    Messages:
    842
    Whats your take on this Ellen?
     
  3. mmgirls

    mmgirls Approved members

    Joined:
    Nov 28, 2008
    Messages:
    6,030
    So, if they have a patent on encapsulated islets to be a biological cure then does that mean other could not bring theirs to market?
     
  4. sszyszkiewicz

    sszyszkiewicz Approved members

    Joined:
    Dec 24, 2013
    Messages:
    842
    No, but when that organization/group did bring it to market, if it "infringes" on this patent, then they would have to pay royalties.

    Patent law is a double edged sword. You want to protect your ideas, but patents are often used to twist things in a manner that limits innovation. In the computer science world there are companies that do nothing but have a patent portfolio and collect royalties, suing other companies over vague notions of concepts and who came up with an idea first. After a while, the truth is lost in the legalese.

    I just hope this company is actually working towards a cure and not just trolling patents.
     
    Last edited: May 2, 2014
  5. mmgirls

    mmgirls Approved members

    Joined:
    Nov 28, 2008
    Messages:
    6,030
    So in the end the biological cure would most likely cost more, o'well.

    For me if both the Artificial/ Bionic pancreas and encapsulated islets were to both reach the market on the same day I would choose to have my dd do the encapsulated islets. It is a more complete cure that is sort of "set it and forget it", allowing for natural feedback systems and counter regulatory actions.
     
  6. sszyszkiewicz

    sszyszkiewicz Approved members

    Joined:
    Dec 24, 2013
    Messages:
    842
    It gets really funky with patents. The definition of "prior art" etc... For example, Diabecell, which almost has a product (but not in the USA) has encapsulation technology without immunosuppression. So like i said, with patent law, and how intellectual property attorneys view the world, things get really confused, and it can put a damper on innovation. Investors look to minimize risk, and the threat of patent lawsuits tends to increase the level of risk, and thus decrease investment/risk taking.

    So I hope these guys have something real.
     
  7. MHoskins2179

    MHoskins2179 Approved members

    Joined:
    Mar 14, 2010
    Messages:
    494
    It's very interesting what Encapsulife is working on. I did a post on this research in early April over at D'Mine, so for those who are interested here's a link to that post: http://www.diabetesmine.com/2014/04/encapsulife-diabetes-research-from-outer-space.html.

    They are developing a very specific method of encapsulation, based on microgravity tech that Dr. Wang first came across when he was in astronaut in space on the Challenger back in the early 80s. That's what the patent is focused on -- not the broader arena of encapsulation.

    Will be interesting to see how this develops, along with others in the encapsulation world like ViaCyte that is apparently close to some news of its own.
     
  8. Don

    Don Approved members

    Joined:
    Sep 23, 2010
    Messages:
    126
    I am hopeful (actually teared up imagining life with this). At minimum, it is a relief to see people working on an idea that follows common sense. Encapsulation at least addresses the autoimmune attack vs decades of ongoing work with beta cell transplants which require immunosuppressants. I would not consider such a situation requiring immunosuppressants to be a cure.
     
  9. mmgirls

    mmgirls Approved members

    Joined:
    Nov 28, 2008
    Messages:
    6,030
    I went to JDRF function a few years ago and I learned about this whole concept of encapsulation and I think it just makes so much sense, I am so very hopeful for this concept to come around rather than the artificial/Bionic pancreases.

    There are many different people working on this sort of biological cure and that is very encouraging.
     
  10. Turtle1605

    Turtle1605 Approved members

    Joined:
    Jan 6, 2012
    Messages:
    353
    I'm still confused on whether this is good or bad. I guess maybe we don't really know. My heart hopes that they got the patent because they know it will be successful and will be available soon :).
     
  11. Ellen

    Ellen Senior Member

    Joined:
    Oct 22, 2005
    Messages:
    8,240
    I'm all for encapsulation - but we need a supply of islets to encapsulate. I'm sure that every method will be somewhat different. Just because there's a "patent" doesn't necessarily mean it works. Looking forward to seeing data.
     

Share This Page

- advertisement -

  1. This site uses cookies to help personalise content, tailor your experience and to keep you logged in if you register.
    By continuing to use this site, you are consenting to our use of cookies.
    Dismiss Notice