We always check our daughter throughout the night. At midnight then again between 3-4am depending on the previous reading and possible correction. Sometimes she's checked again at 6am when one of us is getting up for work and then again prior to breakfast. Our endo also told us not to check her through the night, only at 3 am if we were really worried. Are they kidding?!? When wouldn't we be worried?? We've caught way too many unexpected lows in the middle of the night to ever stop checking. The endos are very smart but they don't live and breathe it like we parents do. ALWAYS trust your instincts.