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Cured in Mice....again

Discussion in 'Research' started by fishface326, Mar 3, 2021.

  1. fishface326

    fishface326 Approved members

    Jun 5, 2018
    Cell conversion method cures diabetes in mouse models (newatlas.com)

    'The researchers used manmade proteins, called monoclonal antibodies, designed to help the immune system identify and neutralize glucagon receptors in mouse models of the disease. These rodents had been genetically engineered to suffer a loss of beta cells, and despite this, the researchers found a weekly dose of their antibody treatment effectively lowered their blood sugar levels even weeks after the treatment had stopped, effectively curing them of the condition.

    This turned out to be the result of an increase in the quantity of cells in the pancreas, including an uptick in beta cells, as a result of the antibodies. Using a technology called lineage tracing to track the sequence of cell divisions, the team found that some of the alpha cells that produce glucagon had been converted into beta cells that produce insulin instead.

    Through followup experiments on more mouse models, the team was able to confirm that the antibody treatment had the same effect when human alpha and beta cells were injected into the rodents, in a model closely mimicking the human system"
  2. rgcainmd

    rgcainmd Approved members

    Feb 6, 2014
    Hope has become too expensive for me.

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