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Cord blood

Discussion in 'Parents of Children with Type 1' started by samson, Jan 9, 2017.

  1. samson

    samson Approved members

    Joined:
    May 11, 2016
    Messages:
    117
    My news feed popped up with this article about a trial to use cord blood to treat multiple antibody positive kids to prevent T1D. Does anyone know the rationale and evidence behind this practice? Or is it just a Hail Mary pass since you've already got the cord blood banked?
     
  2. joshualevy

    joshualevy Approved members

    Joined:
    Dec 30, 2008
    Messages:
    590
    The idea behind it is that cord blood is rich in T-reg cells. These are cells which help regulate the immune system. Since type-1 diabetes is caused by an immune system which is overly active and targeting the wrong cells, more T-reg cells could be a cure or prevention. The quote from the researchers is this: "The hypothesis is that autologous cord blood, when reinfused into children at high risk of developing type 1 diabetes, will resotre [sic] immune tolerance and prevent or mitigate the development of type 1 diabetes."

    Similar clinical trials have been run on people in the honeymoon phase (already diagnosed with type-1 diabetes), and these trials were unsuccessful. However, the children in this study have not yet been diagnosed, so the researchers are hoping for a preventive effect. Preventing T1D might be easier than curing it.

    This trial has been on-going since 2013, and their goal is to enroll 20 people. I would call it a phase-I pilot trial. There is no control group; everyone gets the treatment, but you need to have stored cord stem cells and 2 or more autoantibodies.

    You can read my previous blogging about the honeymoon trials here:
    http://cureresearch4type1diabetes.blogspot.com/search/label/Cord Blood

    There is more information on this exact trial here:
    https://parentsguidecordblood.org/sites/default/files/articles/CoRD_Scientific_Summary.pdf
    https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=363694
    https://www.insception.com/news-pre...l-launches-cord-reinfusion-in-diabetes-study/


    Joshua Levy
     

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