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Cord blood

Discussion in 'Parents of Children with Type 1' started by samson, Jan 9, 2017.

  1. samson

    samson Approved members

    May 11, 2016
    My news feed popped up with this article about a trial to use cord blood to treat multiple antibody positive kids to prevent T1D. Does anyone know the rationale and evidence behind this practice? Or is it just a Hail Mary pass since you've already got the cord blood banked?
  2. joshualevy

    joshualevy Approved members

    Dec 30, 2008
    The idea behind it is that cord blood is rich in T-reg cells. These are cells which help regulate the immune system. Since type-1 diabetes is caused by an immune system which is overly active and targeting the wrong cells, more T-reg cells could be a cure or prevention. The quote from the researchers is this: "The hypothesis is that autologous cord blood, when reinfused into children at high risk of developing type 1 diabetes, will resotre [sic] immune tolerance and prevent or mitigate the development of type 1 diabetes."

    Similar clinical trials have been run on people in the honeymoon phase (already diagnosed with type-1 diabetes), and these trials were unsuccessful. However, the children in this study have not yet been diagnosed, so the researchers are hoping for a preventive effect. Preventing T1D might be easier than curing it.

    This trial has been on-going since 2013, and their goal is to enroll 20 people. I would call it a phase-I pilot trial. There is no control group; everyone gets the treatment, but you need to have stored cord stem cells and 2 or more autoantibodies.

    You can read my previous blogging about the honeymoon trials here: Blood

    There is more information on this exact trial here:

    Joshua Levy

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