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Clinical Trial

Discussion in 'Adults with Type 1' started by ResearchChick, Jan 27, 2020.

  1. ResearchChick

    ResearchChick Approved members

    Oct 31, 2019
    Ive posted in the Research Forum about a Clinical Trial that I had the potential to participate in.

    It has officially started and I figured I'd post periodic details and updates. Think of it like a blog entry.

    The basis of the trial does not appear to be plausible to me as there is no immunosupression, but it was free, so i figured "what the heck... lets give it a whirl".

    As described in Research Forum, the study began with them giving me injections to "grow more of my own stem cells (white blood cells)". The side effects of which were greater than anticipated (joint/bone/muscle pain), but manageable. Then they extracted bone marrow from my hip, put it in a centrifuge (or something) and injected it back into me intravenously.

    Most posts will likely only be an update of insulin dosage... cus that's all I'd be interested in when looking at something like this. Expect updates no more frequently than monthly. Was told to not expect insulin changes for at least 3-4 months.

    Prior to study details:
    (note... was on mild diet for my own reasons, not the study's so daily dose is lower than normal for me even)

    Some details may be obscured to protect privacy.

    Type of Diabetes: Type 1
    Age: 41
    Years with diabetes: 38
    BMI: 21.61
    HbA1c: 6.7

    Insulin Dose before study commencement (via pump):
    7 day average - 25.07u
    14 day average - 25.88u
    30 day average - 27.82u

    Edit: adding in typical basal since what you eat can largely affect your daily dose. Basal, while can still vary, is a lil more consistent.

    daily basal: 10.774
    Last edited: Feb 1, 2020
  2. ResearchChick

    ResearchChick Approved members

    Oct 31, 2019
    I had fully planned on posting updates on a monthly basis... even if nothing happened. But, y'know how it goes.

    In any event, since I will be heading back to work next week after our local "lockdowns", I thought I'd give a very very general update without specifics at this time as I do not believe them to add much value right now, as I am eating a lot more and gained about 5 lbs, so of course insulin usage has at the very least gone up a little if the trial had not produced spectacular results so far (which it hasn't really).

    Right now is about the cusp of the timeline of when they suggested "if it works, don't expect (incremental) results until at least 4 months", so its about 4 months.

    I so far have seen little to no observable reduction of insulin requirements at this point. However, and this is highly unscientific and anecdotal, in the past week I have noticed considerably more stable blood sugars (a lot of 110 and 112 blood sugars). But this is not long enough to base assumptions off of. I've had fewer highs (except for when a site failed and I got up to 400, but it came down quickly once a new site was inserted and correction dose given) and I have been doing some "zoom exercise sessions" due to covid-19 lockdowns, instead of what I usually do for exercise, and I always used to disconnect for exercise sessions of 1.5 hours or less (if rigorous), but used to deal with spikes even after connecting back (sometimes even when trying to dose for lost insulin), but have not had those problems recently, I connect back, do not have to dose for lost insulin and sugars remain stable after hooking back up.

    It might mean something, but doesn't seem like anything to celebrate at this point yet.

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