- advertisement -

Celiac Disease Blood Work

Discussion in 'Celiac' started by aklap, Jan 30, 2010.

  1. aklap

    aklap Approved members

    Joined:
    Aug 18, 2006
    Messages:
    732
    Celiac Disease Blood Work

    Doctors will usually start with a set of blood tests called a Celiac Panel that should consist of the tests below. If the panel does not include all tests, you may not get the entire picture. Be aware: Most doctors will run the tTG tests.

    Please request your doctor to run ALL of these tests. Not all Doctors will know about Celiac Disease (CD) and may be unfamiliar with proper testing. This is where educating yourself becomes important.

    You must be consuming gluten in order for these tests to be as accurate as they can be. Do not go gluten free (GF) before these tests are done.

    If the blood tests come back positive, they may want to scope you to check for intestinal damage (the gold standard for Celiac diagnosis).

    A Complete Celiac Blood Panel:

    • Antigliadin IgA and IgG*

      Most doctors exclude these tests, however, Dr. Alessio Fasano, Director of Univ. of Maryland Center for Celiac Research includes them in his blood work panel.

      Dr. Fasano also reports that 60-70% of his patients that come to him thinking they have celiac disease, in reality he says they have Non-Celiac Gluten Sensitivity. The Antigliadin test is the best way to check for Non-Celiac Gluten Sensitivity.

      See more info on Non Celiac Gluten Sensitivity Testing in the Explanation of Blood Test Section below. Pay close attention to Dr Ford & Dr. Peterson's sections.

      *The Antigliadin IgA and IgG tests have fallen out of favor due to the lack of specificity [other medical issues can be the cause of these antibodies]. However, some organizations and Doctors do feel these tests are of importance and still include them in their panel of tests. Gluten maybe an issue, and should be investigated a bit further. These tests ARE included in followup testing to determine dietary compliance, so there is value to them.


      Deamidated Gliadin Peptide IgG & IgA (DGP-IgG and DGP-IgA)

      • The DGP test is the new kid on the block and will likely over take tTG as the "test of choice" to detect intestinal damage (celiac disease). It's more specific and more sensitive.

        As if celiac testing isn't confusing enough, this new test is being called the "Gliadin Test". This is confusing due to the older (now disappearing) Anti-Gliadin Autobody test listed above. The AGA & DGP tests look for two completely different things (see the explanation section below). Another problem is that labs are replacing the AGA tests for the DGP tests.


      [*]Anti-tissue Transglutaminase Antibody (tTG) IgA
      Anti-endomysial (EMA)

      • An indicator of villi damage [slight damage is not always detected. See More Info Section below].
        These tests are highly specific to CD.
        However, autoimmune diseases can skew the results of these tests

        http://www.celiacdiseasecenter.columbia.edu/C_Doctors/C05-Testing.htm



      [*]Total serum IgA
      • Rules out IgA deficiency. If someone is not producing the IgA antibodies, it will skew the results of any IgA test. This must be run to ensure proper IgA test results


      [*]Anti-reticulin IgA
      • Rarely used but, a very thorough doctor will include this

    Prometheus Lab's Serology Product List - Note, recently this lab has switched out the Anti-Gliadin Autobody tests for the Deamidated Gliadin Peptide Tests :(
     
    Last edited: Dec 22, 2010
  2. aklap

    aklap Approved members

    Joined:
    Aug 18, 2006
    Messages:
    732
    Explanation of Blood Tests

    • American Celiac Disease Alliance - Diagnosis

      http://glutendoctors.blogspot.com/

      Dr. Petersen of HealthNow Medical explains the blood tests in her blog post titled "Interpreting Lab Work"


      *The Antigliadin IgA and IgG tests have fallen out of favor due to the lack of specificity [other medical issues can be the cause of these antibodies]. However, some organizations and Doctors do feel these tests are of importance and still include them in their panel of tests. Gluten maybe an issue, and should be investigated a bit further. These tests ARE included in followup testing to determine dietary compliance, so there is value to them.
     
    Last edited: Dec 22, 2010
  3. aklap

    aklap Approved members

    Joined:
    Aug 18, 2006
    Messages:
    732
    Explanation of Blood Tests Continued

    Dr. Rodney Ford - Recommended blood tests for Gluten problems


    Dr. Rodney Ford's Gluten-Free Planet Blog Post: Gluten blood tests - IgG-gliadin


    *The Antigliadin IgA and IgG tests have fallen out of favor due to the lack of specificity [other medical issues can be the cause of these antibodies]. However, some organizations and Doctors do feel these tests are of importance and still include them in their panel of tests. Gluten maybe an issue, and should be investigated a bit further. These tests ARE included in followup testing to determine dietary compliance, so there is value to them.
    [/list]
     
    Last edited: Dec 22, 2010
  4. aklap

    aklap Approved members

    Joined:
    Aug 18, 2006
    Messages:
    732
    Additional Testing

    • Due to the nature of Celiac Disease, it very common to find nutritional deficiencies. It's important to know this information as well.

      Dr. Peter Green [world renowned CD expert] suggests this:

      http://www.enabling.org/ia/celiac/medcare.html

      Initial Assessment and Follow-up Care of Celiac Patients, by Peter Green, MD, summarized by Sue Goldstein

      Even though it's not in this list - B12 should be checked as well.


    More info on Diagnostic Testing:

    • Diagnostic Testing can be found in the The Gluten File

      Clan Thompson's Testing and their Results. This is a really great resource. Please, spend some time looking this over.

      Prometheus Labs CeliaPlus. Prometheus Labs is a respected and well known lab for processing Celiac Blood Panels. Note: You will be asked if you are medical professional. Of course you are! ;)

      Gluten Intolerance Group - Celiac Disease

      Celiac Disease Center at Columbia University

      False Negative Serological Results Increase with Less Severe Villous Atrophy




    Testing in children:

    • http://www.ncbi.nlm.nih.gov/pubmed/18852634?dopt=AbstractPlus

     
    Last edited: Dec 22, 2010
  5. aklap

    aklap Approved members

    Joined:
    Aug 18, 2006
    Messages:
    732
    Bump for Jaque
     
  6. aklap

    aklap Approved members

    Joined:
    Aug 18, 2006
    Messages:
    732
    back to the top
     
  7. khannen

    khannen Approved members

    Joined:
    Mar 27, 2007
    Messages:
    714
    I've read through this but am too tired to have any of it make much sense. Lol
    Shealyn was just tested again with annual bloodwork that includes celiac testing apparently.

    These good results? Any reason to look further?

    TISSUE TRANSGLUTAMINASE IgA 6
    IMMUNOGLOBULIN A 68 mg/dL
     
  8. aklap

    aklap Approved members

    Joined:
    Aug 18, 2006
    Messages:
    732
    back to the top
     
  9. aklap

    aklap Approved members

    Joined:
    Aug 18, 2006
    Messages:
    732
    back to the top
     
  10. aklap

    aklap Approved members

    Joined:
    Aug 18, 2006
    Messages:
    732
    back to the top
     
  11. aklap

    aklap Approved members

    Joined:
    Aug 18, 2006
    Messages:
    732
    back to the top
     
  12. aklap

    aklap Approved members

    Joined:
    Aug 18, 2006
    Messages:
    732
    back to the top
     

Share This Page

- advertisement -

  1. This site uses cookies to help personalise content, tailor your experience and to keep you logged in if you register.
    By continuing to use this site, you are consenting to our use of cookies.
    Dismiss Notice