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Can someone help me understand what this means?

Discussion in 'Research' started by fishface326, Jul 29, 2020.

  1. fishface326

    fishface326 Approved members

    Joined:
    Jun 5, 2018
    Messages:
    14
    This Italian company just got a big round of funding, including from JDRF. What does this phase mean?

    "Enthera's lead program Ent001 is the only drug in development with the potential to restore the endogenous pancreatic stem cell compartment in T1D"

    About Enthera

    Enthera Srl is a biotech company developing first-in-class biologics to transform the treatment paradigm of specific autoimmune conditions by re-establishing stem cell capabilities in a non-traditional way. The Company’s primary target indications are type 1 diabetes (T1D) and inflammatory bowel disease (IBD).

    Enthera's pioneering approach capitalizes on the key discovery of the IGFBP3/TMEM219 pathway, which is involved in beta cell and stem cell apoptosis in pancreas and gut, respectively.

    The Company is building a pipeline of inhibitory monoclonal antibodies (mAbs) and fusion proteins targeting the pathway via multiple angles. Its lead program Ent001 is the only drug in development with the potential to restore the endogenous pancreatic stem cell compartment in T1D as well as the original intestine structure in IBD, in order to re-establish organ function.

    Enthera is a private company headquartered in Milan, Italy and founded in 2016 by Prof Paolo Fiorina and Dr Francesca D’Addio at BiovelocITA, an Italian biotech accelerator. The Company is backed by Sofinnova Partners and JDRF T1D fund. Enthera’s discovery engine and assets are protected by a broad portfolio of patents.

    For more information, visit https://www.entherapharmaceuticals.com/
     
  2. joshualevy

    joshualevy Approved members

    Joined:
    Dec 30, 2008
    Messages:
    650
    Sure:
    1. The stuff about "pathway" means they think they have found a cure for type-1 diabetes.
    2. The stuff about "monoclonal antibodies" means that if it does cure type-1 diabetes (a big if!) then they can package it up and sell it.
    3. I looked at their web page, under pipeline, and they are currently in "pre-clinical development" which means they have not yet tested on people, so they are more than 15 years away from having a product. Maybe a lot more than 15 years, and that assumes that it turns out to work.
    Joshua Levy
     

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