Emily came home from camp Saturday. She had a blast and I'm glad. However, the staff was so conservative they let her run way too high IMO. I expected to see a lot of 200's, but she had several days of 300-500's and 2 times with significant blood ketones (2.6). Prior to this she's only had ketones twice--0.6 during an illness and 1.6 after a site failure. The staff was a little freaked over her CGMS and turned the high alarms OFF (rather than turning them up to say 250 ). Ever since she got home (she was 498 when we picked her up), we've had to steadily increase everything all-around to keep her anywhere near the 100's. She's frequently in the 200's anyway, so we made more changes today. So here's my concern: 1. Her basal rate has more than tripled. 2. Her ICR number has decreased by 6 points. We're WAY into the single digits now and still seeing huge spikes despite 30 minutes of pre-bolus 3. Her ISF has decreased by 30 points I'm really concerned. She did come home with "camp crud"--post-nasal drip, headache and feeling a little under the weather. But no fever and nothing I'd keep her home for. She does require a lot more insulin for illness, but she doesn't really seem ill this time. So is this insulin resistance from a week of being sky-high? Did they effectively kill off her 2 remaining beta cells? (plus the crud)? Or could this be puberty? We are perplexed and quite frankly freaked out over the amount of insulin she's getting. The TDD is about double. We DID do the following: 1. Change sites--many time (old ones looked fine) 2. Change insulin bottles--4 times 3. Change sets--4 times (always looked fine) 4. Checked for lipohypertrophy--none 5. Tested the pump by giving her a shot rather than a correction bolus--no difference Has anyone had an experience like this? Anyone got any ideas?