It turns out Alex is allergic to Apidra. Thanks to dqmomof3 for clueing us in that this might be the case. I figured I'd post this, in case anyone else was seeing the same symptoms. It started off so great. When we switched from Novolog, it worked wonderfully, in fact, we had to reduce the basal down much lower than ever, to keep him from going low. Then, the rashes started. Under the pod, would be a big nasty, rash where his skin. It wasn't just red and itchy, the skin felt like it had expanded out and become very thick, almost brittle. But, the insulin was still good, so we stuck with it. We've had reactions like this before, just less agressive, so we figured it was just the normal irritation coming back to roost. Then last weekend happened. On Friday night, his BG soared up to 400 and just stayed there. Blood ketones went to 1.4. I corrected and corrected, and nothing happened. I changed his basal from 0.35u/h to 1.0/u/h. No matter what we did, the ketones never fully cleared, they would vary from 0.5-2.0, even with huge amounts of insulin. We were able to get the BG down to the low 200, and occasionally below, but they would just jump back up as soon as he ate anything. You should know I'm no ketone newbie, we've gotten them maybe 50 times and cleared them out successfully. This was the first time that we had real trouble clearning them out. Yesterday we changed back to Novolog completely with a new site, and... the ketones are all gone, and the BGs are back to their... well, not great, but back to their crazy old self, just less crazy. As for the rashes, I do hope they go away. We will see.