Well, this just sucks. I was diagnosed with hypothyroidism with a TSH of 6.0, but it explains why I have felt tired as hell for the last year. Anyhow..... Since I started taking synthroid a couple days ago, my insulin requirements have tripled. I am using a BASAL RATE of 4.1 units/hr, and CORRECTION FACTOR of 1u/20mgdl>120, and a CARB RATIO of 1:8. I only weigh 140lbs. I am using close to 180-200 units a day of Apidra now. This is just berserk. Prior to starting synthroid, I was averaging TDD of around 90-100 units/day, highest basal was 1.7u/hr. Now up to 4.1u/hr and BG's still running 170-200 consistently. Help???