Modern-Day Clinical Course of Type 1 Diabetes Mellitus After 30 Years' Duration Arch Intern Med. 2009;169(14):1307-1316. http://archinte.ama-assn.org/cgi/content/short/169/14/1307 This study showed that intensive control reduces the incidence of proliferative retinopathy, nephropathy, and cardiovascular disease signficantly compared with non-intensive control. DCCT incidence of these complications were 50%, 25%, and 14% after 30 years. In the intensively treated group, however, the rates were 21%, 9%, and 9%, and less than 1% went blind, needed a kidney transplant, or lost a limb. These results, while not where we want them (0% across the board), are exceptionally positive and reinforce the importance and benefit of intensive management.