I'm trying (sleepily) to ponder why we have had some lousy nights with lows lately. Why we are having them is one issue but for now I am trying to figure out why they are not responding as I would expect. When we were first diagnosed and for many months after that we treated lows with about 15 grams which was usually a juice box. A few months ago as she started dropping out of honeymoon we found that even 5 grams would sometimes bump her up 100-200 points. So most of the time now we are treating lows with 5-7 grams and 10 at the most. There has been no problem or change with this during the daytime. Then three weeks ago we had a really bad night (happened to be our first night with dex). She had eaten dinner well but had already dropped lower than I liked before bed and we gave her a snack. Right now I can't recall how low it went or what we gave. I think we actually treated a mild low and then bolstered it with a snack. She was over a hundred before she went to sleep and 29 when dex alarmed low (reading 67) 45 minutes later. Yikes! I will try not to bore with details but basically I treated her with 15 grams and rechecked in 15 min and she was coming up nicely. Dex started trending up then down again 45 min later. Finger sticked showed 45. Repeat (treat, recheck improving, then low again 45 min later). Treated again and finally numbers climbed and then stayed around 250 for the next 12 hours. I don't know if it all finally absorbed or her liver kicked in. This all took place from about 10 to 2 and her humalog was given around 6:30 or maybe 7. Three days ago we had almost identical night except numbers not quite as low (45 to 70). Gave 17 grams bedtime snack because she was 94 about 2-2.5 hours past humalog. Was hoping to head off a low but ended up battling lows from around 10-2 again with nearly 3 boxes of juice given periodically as she dropped again and again. Last night was a little different. Fine at bedtime and good numbers most of the night then dropped at 4:30 to 61. treated with 1/2 juice box because I reasoned there was no humalog on board AND I am a slow learner. Waited too long I suppose and checked her 30 min later and she was 55. Gave the rest of the juice box and went looking for more since I had exhausted my bedtime stash and had stupidly not fixed this while I was waiting the first time. By the time I found more I decided to wait the full 15 min rather than giving more immediately. So checked her again a few minutes later and still 54. Gave another 3 ounces and finally she started climbing up. I am not understanding why she is requiring 40-60 grams to treat lows at night time even when she has only the tail end or no humalog on board at all. Previously when we treated lows at night (which was rare) she responded quickly to 7-15 grams. I am wondering how aggressively I should be treating the low the first time. Should I immediately give 30 grams for example rather than worrying that it will send her over 400. Then I suppose I need to figure out why it is happening at all. I have been fiddling with our lantus dose. 3 units seems too little but 3.2 sometimes seems to be too much. I'm wondering whether we need to split the dose. Anyway thats another question though and mostly I am wondering about the lack of response to the carbs at night.