We've been pumping since July. Am I imagining things or has anyone else noticed significant differences in insulin absorption with different sites? We rotate as suggested by our endo by making diagonal zig zag changes in succession in one area before switching to another. The theory being that you get less scar tissue long term because you are fully using an area vs switching back and forth (say left to right leg) each time has therefore forgetting exactly where the last site was. Anyhow, this gives me a good chance to observe and perfect basals, I:C, etc while in a site area. However, I have noticed a pattern of pretty dramatic insulin usage when switching from thigh to buttocks. The TDD is 25-30% less when using a thigh site vs an upper buttocks site. Endo says there shouldn't be much difference. So, what are my other differentials? It happens every.single.time we switch locations (about every 2 weeks). I have recorded one set of basals/ratios for the thighs and another for the rear!