We've had a few impossible nights lately where I just can not get any night time corrections to work for Charlotte. I think several things may need tweaking, but I'm starting with the ISF. Currently, for the evening it's set at 300. (it's been a while since I changed it) In Pumping Insulin there's a chart that estimates ISF, but it starts at 18U TDD and Charlotte is only getting 11-12. But looking at the chart, I'm guessing a TDD of 12 would have an ISF of about 180? That seems really low. I just need a jumping off point... right now even if I give 20-30% more than the correction suggests, she's still even higher 2 hours later. And I don't think it's a basal problem. B/c if her bg for the evening starts out in range, I have to turn her basals down 30% for a few hours to keep her from dropping even more.