I've gone through some of the footnote studies listed by the JDRF as justification for the 5% figure (or 1:20 ratio) behind the ad. This is what I found. It's unfortunately not complete with every footnote/study flushed out, because I don't have access to some of the full text without purchasing it. The Cryer studies appear to be citing his own articles and studies, or some of these others below as the more recent ones showing higher % of hypo-caused deaths.  Laing SP, Swerdlow AJ, Slater SD, et al. The British Diabetic Association Cohort Study, I: all-cause mortality in patients with insulintreated diabetes mellitus. Diabet Med. 1999;16:459-465. - My review: 949 people with Type 1 died out of 23,752 (4%), with many being attributed to acute metabolic complications such as Lows or DKA.  Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study Research Group. Long-term effect of diabetes and its treatment on cognitive function. N Engl J Med 2007;356(18):1842?52. - My review: Of the 53 deaths during the DCCT and the EDIC study, 3 were attributed to hypoglycemia and all 3 occurred during the EDIC study. ? (5.6%)  Feltbower RG, Bodansky HJ, Patterson CC, et al. Acute complications and drug misuse are important causes of death for children and young adults with type 1 diabetes: results from the Yorkshire Register of diabetes in children and young adults. Diabetes Care 2008;31(5):922?6. My review: 4,246 individuals were followed and overall, 108 patients died overall (2.5%). However, 47 of 108 deaths (4%) occurred from diabetes complications, 32 of which were acute and 15 chronic.... So, by extension, something like 1.1% may have died from a Low.  Skrivarhaug T, Bangstad HJ, Stene LC, et al. Long-term mortality in a nationwide cohort of childhood-onset type 1 diabetic patients in Norway. Diabetologia 2006;49(2):298?305. My review: 103 of 1,906 died (5.4%), with acute metabolic complications such as Lows or DKA accounting for the most deaths at 32% of the total. So, by extension: 1.7% could have been result of Lows. Additionally, one I found from September 2011 study - Time trends in mortality in patients with type 1 diabetes: nationwide population based cohort study My review: 1338 deaths occurred out of 17,306 people (7.7%), with data showing mortality rate decreasing over time for those diagnosed before they were 14. I couldn't conclude what this said about Lows as a cause, as most of it goes over my head... but link is here: http://www.bmj.com/content/343/bmj.d5364.full Also, saw a EuroDiab study from June 2007 that said 141 deaths out of 28,887 people with Type 1 were recorded (4.8%). However, only 35% of those deaths were directly related to D and many mentioned DKA specifically. Five were specifically caused by Lows. So, there, you're basically looking at less than 1% actually being proven to be a result of a Low.