I posted a few days ago about DS having strep and dealing with his recent numbers. At this stage in the game, he's been on amoxicillin since this past Friday, and his numbers have spiraled completely out of control. I called his endo this morning, and she strongly advised against changing I:C ratios or his basal and told me to just correct when necessary. The only issue I have with that is that's exactly what we've been doing and it's not working. I'm not sure if the antibiotic is what's causing the issues with his numbers, or if it's the strep, but we're regularly seeing numbers anywhere between 250 and 410. Against the endo's wishes, today I increased his Lantus from 4u to 4.5 to help battle overnight numbers, and I reduced his breakfast I:C ratio from 1:30 all the way down to 1:20. I checked at the three hour mark and he was sitting at 350 even . I gave a 1u correction along with fluids to help flush out the excess sugar, and even went so far as to replace both vials of insulin with new ones just in case. I've been checking for ketones regularly seeing as though his numbers have been high for quite some time, and thankfully there haven't been any. I'm just so frustrated right now because it seems that nothing I'm doing regarding giving extra insulin seems to be working. I was up with him all night last night giving corrections. Before he went to bed he was 270. I gave him .5u as a correction which typically brings him down about 100 points. I checked two hours later and he had only dropped to 250. After two more 1u corrections over the span of several hours and constant glucose checks, I was finally able to get him down around 180. I continued checking him each hour after that just to see what was happening, and his glucose just kept rising, resulting in a 260 when he woke up this morning. I know that insulin resistance while sick is a fairly common issue, but my son is absolutely miserable and I can't blame him. Is this something I just have to ride out until the 10 days of antibiotics finish this coming Sunday, or is there a better way to go about this? Any suggestions or advice would be incredibly helpful right now!