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DRI makes some progress on the insulin producing cell front

Discussion in 'Research' started by sszyszkiewicz, Nov 24, 2015.

  1. sszyszkiewicz

    sszyszkiewicz Approved members

    Dec 24, 2013
  2. Ed2009

    Ed2009 Approved members

    Mar 3, 2009
    Very interesting article, a first in some time indeed, worth reading. In short:

    "We discovered that the exposure of human pancreatic exocrine cells to BMP-7 alone results in their efficient conversion into insulin-producing clusters that respond to glucose both in the laboratory setting and after transplantation into diabetic rodents."

    So it seems that they took the cells from the bulk of the pancreas (called NEPT tissue in the article), exposed it to BMP-7 protein (I read it is a protein, FDA approved, used to treat/prevent the growth of some cancers), and these cells either in vitro and transplanted to mice, were responsive to glucose by generating insulin 50 to 250 times more than the same cells tinkered genetically.

    If anyone has the time, the article is a very interesting read. Thanks SSZYKWZ.

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