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Denise Faustman Update

Discussion in 'Parents of Children with Type 1' started by shume24, Aug 9, 2007.

  1. shume24

    shume24 Approved members

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    I donate to Denise Faustmans research and got this update the other day so thought I would share. The report is a PDF file and I put it on rapidshare just hit the link below then click on the free download button and you can download.

    Dear Friends,

    I hope this message finds you and your families well and enjoying theSummer. We're busy here in the lab. In the attached newsletter, you will find the most recent updates from our lab, and an overview of where we have come from in our quest to find new cures for type 1 diabetes and other autoimmune diseases. As always, we are happy to hear back from our patients, friends and supporters, so please keep in touch.

    Warmly,

    Denise Faustman, MD, PhD

    http://rapidshare.com/files/47885813/FaustmanNewsltrSummer071.pdf.html
     
  2. D-Dad

    D-Dad Approved members

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    Exciting to see her work go to human trials. Thanks. There are so many smart people hitting this from different angles....... something's got to hit.
     
  3. missnme

    missnme Approved members

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    Thanks for sharing this info. I hadn't heard of her until I read the Cheating Destiny book that so many parents recommended on this site. Very encouraging.
     
  4. hold48398

    hold48398 Approved members

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    Thank you for the link to the article. I have great hopes in Dr. Faustman's research. Maybe we will try to raise money for her studies this year rather than going with the JDRF. 2008 can't some soon enough!!
     
  5. WestinsMom

    WestinsMom Approved members

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    Actually we are doing a letter writing compaign for The Lee Iococca Foundation this year instead of JDRF. JDRF got rid of the Kalamazoo walk this year, so I thought this might be a nice change!
     
  6. Ellen

    Ellen Senior Member

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    For some reason the link didn't work on my computer. The last update I read from her stated they still have to determine dosing in mice. That sounds like a long way from humans to me.
     
  7. badshoe

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    I can't get to the link.
     
  8. Twinklet

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    I've considered raising money for Denise Faustman's research rather than JDRF as well. Still musing over that one. Thanks for the update.
     
  9. rmccully2000

    rmccully2000 Approved members

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    Here is another link along with the text

    http://www.faustmanlab.com/News/FaustmanUpdateJune2007.pdf

    Research Update from the Faustman Lab
    The Faustman Laboratory is progressing towards clinical trials with BCG, a generic drug that may help to remove the disease causing white blood cells of type 1 diabetes, also known as T cells. This trial is unique for many reasons. This is a trial for people who already have diabetes. The goal is to reverse established diabetes, not just halt new onset type 1 diabetes.
    Secondly this trial is unique in that it will use a generic drug, BCG, that
    is approved in the US for other disease indications and thus has a very safe toxicity profile. Thirdly, the goal of using BCG is targeted disease removal of only autoreactive cells in order for the pancreas to be able to regenerate and hopefully restore blood sugars.

    As part of the effort to translate diabetic mouse cures to human cures for diabetes, the Faustman Laboratory is devising new blood tests to monitor for early signs of an effective dose of BCG. These blood tests require two development steps. First the Faustman laboratory must take blood and separate the T cells from the blood. For the past year, this important step has been successfully standardized. The standardization of this process involves being able to remove the T cells from blood with high yield,
    viability and purity. This process has been validated in over 266 human blood samples (half of those from type 1 diabetics), exceeding the goal of 50 human samples by this year. The Faustman Laboratory must also automate this T cell separation process, since all clinical tests must be standardized for clinical trials. Automation will remove the variable of manual blood separation procedures. Secondly, the very pure diabetic T cells will then be used in developing clinical assays to quantify the numbers of autoreactive cells before and after treatment with BCG.

    In February of 2007, the Faustman laboratory had successfully created the first automated blood separation method for a tube of fresh human blood. The T cells after mechanical separations were pure, viable and represent high yields from the starting whole blood.

    Furthermore, the Faustman laboratory was also able to demonstrate continued improvement in their capacity to automate this process. It is likely this new robotic process will be applied to the upcoming clinical trials, which will commence in 2008.

    The Iacocca Foundation has made payment for year two funding of this exciting project at the Massachusetts General Hospital. In year two, the funding for the Nathan/Faustman research program will be aimed to translate the diabetes ‘cure’ from mice to humans. The goals will be to: 1) recruit more type I diabetes patients; 2) implement a robotic clinical blood test to characterize the T cell defect in recruited patients; 3) continue drug dosing studies in the NOD diabetic mouse model; and 4) start the BCG administration of drug to patients.
     

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