I opened a new bottle of Apidra on the Sat the 19th. On Wed the 23rd in the wee hours of the morning her blood sugar shot up. I couldn't get it to come down, so by noon I changed out her site and put new insulin in her pump. She dropped back down to 100's a little too fast. But since then she's spiked up (and stayed) in the 300s, only coming down briefly now and then. It takes a lot of insulin to get her back down. Last night I decided it might be a bad bottle of insulin. I figured I'd change it out this morning. However, her bg came down about midnight and stayed in the low 100s the rest of the night. So maybe it's not the insulin since she eventually came down and stayed there? Of course, this morning she's back up to almost 400. She did have a rare Krispy Kreme donut with breakfast. However, I bolused from the Carb King book, and then she didn't eat it all. So she should have had extra insulin on board. Her IOB says it has way more insulin on board than is necessary to bring her back down. But then why the super spike? I'd blame it solely on the donut, except this has been our theme for the last 3 days, so it's something else too. She got a CGM a couple weeks ago, which has been so helpful. I've been whittling down her basal from almost 8 units to just over 6 and upping her ratios, as it seems she was getting too much basal and not enough meal insulin. It seemed to be working. But maybe I need to up the basals again? I'm just at a total loss here. I'd throw out the bottle of insulin, except I'm an insulin hoarder and hate to throw it out if that's not really the issue. And no, I've never checked for ketones. She rarely gets them, and only when she's sick. Besides acting thirsty and whiny the first day of highs, she's been acting totally fine since then.