I think our settings are a bit out of whack and we've been struggling with highs lately. I googled the guidelines on where to start with calculating doses. This is what I found.... Total daily dose- weight in lbs divided by 4 - which for my daughter would be 60/4 or 15 units a day If I go with 50% basal, that would be 7.5 units a day ISF correction- 1800/TDD would be 1800/15 or 120 Carb ratios- 500/TDD would be 500/15 or 33 so 1 unit for 33 carbs Are those guidelines still used often? I know it's just a starting point, but some of them seem WAY off for her. She typically is over 20 units a day with 10 of that being basal. According to this, it would be much less at only 7.5 units. Also, she goes with 1:20 for breakfast and 1:24 at other times. I currently have her ISF set at 100 so that seems to be the only one above that 'fits'. What am I missing? She uses Apidra and we're still getting spikes postmeals. She didn't use to do that nearly as much. Highs seem more stubborn and corrections don't seem to bring her down like they used to. This is a pattern now, so it's not that we just may have a bad vial or something. Anyone willing to offer up some advice? What would you change out first and why? Are there better guidelines to use? Any help would be appreciated. My head is spinning lately.