Have you ever been there? Everything seems to be going perfectly with your ratios and then slowly over a matter of weeks what used to be a walk in the park becomes a nightmare? I've sent the numbers to the Endo, but she's so slow at getting back to me that I thought it might be useful to find out how to figure this out myself. Up until now I really only adjust basil insulin depending on my son's needs and I leave the ratios for Carbs and correction to the Doctor. My son is 10, 66lbs (30Kg) 4"10 seems healthy with no current signs of illness. MDI with NovoRapid (Novolog) and Levemir. I give him 6 units of Levemir 2X day. His carb ratio is 1:20 His correction factor is 1:4 (mmol/l) I think that's like 1 unit to 72 for the U.S. measurement. We traditionally have Breakfast, lunch and Dinner with 60g of CHO each. I give a 10AM and a 3PM 15g CHO UNCOVERED 8PM bedtime snack partially covered. A month ago, the above stats worked so perfectly it was too good to be true. For the past two weeks this has become progressively worse and worse. Now we are seeing 17 (300)-22 (400) 2hrs after meals and over night he's rising from 9 (162)-14 (260)or higher I've raised his Levemir to 9 units 2 x day. And I have started over-estimating his bolus by 0.5 units. For the past 3 days I've totally cut out all uncovered snacks. Todays numbers were: 9.2 last night at 8pm gave 2 units 18.3 this morning at 6AM gave 6 units 17.3 at 9AM and gave an extra two unit correction 3.6 low at 11AM treated lightly 7.5 at 12noon gave 3 units 17.8 at 2:15pm 9.8 at 4pm I've changed vials of insulin just to insure it's not bad. Any advice would be greatly appreciated. If you know a formula to figure this out, please share.