What is the highest single dose of vitamin D ever tested?

[LantusFiend]

There is a clear and present need for me to take insulin; to take insulin because it MIGHT help would be a really different story.

1 in 40 kids with type 1 diabetes in this study had high levels of vitamin D, which was an attempt to back up the claims that more vitamin D is good for diabetics but which did not find that result: http://www.ncbi.nlm.nih.gov/pmc/arti...0/?tool=pubmed

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In research you cited we really don't know how long they maintened their level exactly.. They didn't test vitamin d every week.
I don't see anyone with high level of vitamin d in bloodstream in range 72 mg/dl to 82 mg/dl.. Moreover, we don't have enough blood glucoses monitoring data . It would be interesting to have cgms data over the course of one trial like that. So we could notice all the rebounds,hypo and dawn phenomenon. An adjustment protocol of exogenous insulin should be implented in link with CGMS Data in a trial like that.. We should improve methodology near perfection to get the results we want..

Bad methodology is responsible of poor results( or very limited results) or failure of the researches in past . We focused so much on the compounds but it's right now time to change our focus on importance of phase II methodology.

Vitamin d3 mechanim could act on immune system .Several different researches showed this.. It's not new... High dose of vitamin d3 especially at early stage could induce a reversal or prolong honeyperiod..

A lot of financial interests are no interested to prevent or reverse diabetes t1 through a cheap alternative like Vitamin D3.

Every newly diagnosed diabetes type 1 should be put on vitamin d3 at high dosage immediately by their doctor but it's not commonly applied in clinical practice right now ... I know some doctors may use it in their clinical practice right now. High dosage= at least 10000UI daily or more with frequent monitoring of vitamin d in bloodstream. I know some exceptions are possible but for most people 10000UI of vitamin d3 is very well tolerated.. You could cite some exception in medical rules but can you cite a big research with group of 500 or more at least who found some toxicity at low dosage like 10000UI in healthy subject? I know some subjects with certain diseases could not take vitamin d3 supplement.. but it's an exception to rule.. Rule is vitamin d is not toxic even at high dosage. Try to find toxicity 50000UI daily and under in medical litterature.. I don't talk about one research who studied some exceptions to rule..
Especially if you don't go out frequently or you use suncream or you have a darker skin you are more at risk to absorb less vitamin d from the sun.

Vitamin d3 increase the number of Tregs .. Pancreas and immune cells have both vitamin d receptor..

If you are interested about the topic,, dig the all the medical literature and you will realize , we have a lot more data than the mainstream public knows..

If you know any researches who tested vitamin D3 very high dose with a good methodology on late-stage diabetes t1... let me know..

Some interesting researches I found but it's just partial medical litterature references.

1α,25 (OH)2 D3 appears to have a direct protective effect against pancreatic beta cell
destruction by reducing the expression of MHC class I molecules (Hahn et al, 1997).
In addition, vitamin D appears to increase islet cell expression of the A20 protein,
which has antiapoptotic function (Riachy et al., 2002) (Fig 2). Vitamin D also decreases
the expression of Fas, which is a transmembrane cell surface receptor mediator,
involved in pancreatic beta cell apoptosis (Riachy et al., 2006).

Insulitis can be inhibited by the administration of high doses of vitamin D
in NOD mice (Mathieu et al., 1992)

A pilot study looking at patients with adult-onset latent autoimmune diabetes (LADA)
demonstrated that supplementation with 1,25 dihydroxyvitamin D3 for 1 year resulted
in beta cell preservation, as assessed by C-peptide levels (Li et al., 2009).

Aljabri et al conducted a prospective study in which patients with vitamin D
deficiency were assigned to receive 4000 IU of vitamin D3 daily and had vitamin D 25 (OH)
levels and hemoglobin A1c measured at baseline and at 12 weeks. The results revealed that
the patients who achieved higher circulating levels of vitamin D 25 (OH) had a lower
hemoglobin A1c (Aljabri et al., 2010).

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post in double----error--read post above