Breanne, in thread 'Trialnet free screening for first cousins....recommend it?' you posted ----------T1D is not mendelian. Oh, and one more thing: Diabetes is not a mendelian inherited gene! Recessive vs dominant has nothing do to with it!!! T1D is a VERY complex disease that comes from both sides of the family, and most importantly, the TRIGGER.----------
Will you help me, us, to understand a little better how a person develops T1? My side of the family is D-free. DH side, 4 gens back, had 1 person T1. There are a few T2s but they are either chemical, obesity or diet related and they are not direct blood kin.
TrialNet told us they are studying what may trigger T1. Environment, genetic, inherited.. whatever. Ive heard and read that none or all can trigger it. Sooo... What in the enviroment? How genetic? You already said not inherited. What about childhood immunizations including Flu shots could they trigger this? I was also told that a simple cold could trigger?
What are the names of the 4 different antibodies? Are IA2 and ICA-512 the same? (Our endo said he thinks they are the same but not sure to ask a Trialnet person)
Presuming IA2 and ICA-512 are the same, since each of my sons share 2 of the antibodies, in your expert, granted statistical (I understand all the ifs and butts) opinion, does this put my non-D son at even a higher risk?