Insulins Unplugged (Diatribe)

[Ellen]

This is an interesting article. I wonder how well VIAject will work in the pump. While it is likely to improve postprandial bgs...will there be even less time to figure out there's a pump failure before ketones start to build up?

http://www.diatribe.us/issues/9/learning-curve.php

[Kirsten]

Very interesting.

[twodoor2]

This is an interesting article. I wonder how well VIAject will work in the pump. While it is likely to improve postprandial bgs...will there be even less time to figure out there's a pump failure before ketones start to build up?

http://www.diatribe.us/issues/9/learning-curve.php

I thought the same exact thing as you did when I read this article last week. There are a lot of things to consider with an "ultra-fast" insulin. For some kids with a very long DIA, I would think this would be an improvement (like my daughter), but for others that have a shorter DIA, it might cause potential problems. You also have to worry about smaller doses as well, since those tend to stay in the system for much less time overall.

As for how it will work with basals, that's another ball of wax altogether, and there would have to be signifcant testing to insure that the small doses were spaced properly based on how the pumps work. I hear it has a much higher peak (usually the faster acting, the higher the peak), so I wonder if it would even be suitable as a basal insulin??? It's still too early to probably tell, but I think this new insulin might be better suited to a Lantus or Levemir type of regimen. That's my gut feeling, but I know I might be totally wrong.

[Lee]

I found it interesting that the Dr from the Netherland's was very NPH Friendly - everytime I think of WiIlf, I wonder why there is such a difference in our insulin regimens - his - becuase his daughter was diagnosed 'over there' and he has NPH working like a dream...

[Ali]

Sounds great. It would take some work to manage it on a pump or even with injections because it is different but all the Dr.s/patients figured out how to tweak the insulins that have come along over the last fifty years. I remember those introductions and the adjustments to the new insulins. The pump background issue (if it really turned out to be one) could probably be easily dealt with by giving a bit of your basal via shot once a day similar to what people prone to ketones do now. I for one would love this insulin. Would really help with snacking and eating out when meal timing is unpredictable as well as faster corrections for highs. The corrections would be great. Ali

[twodoor2]

I for one would love this insulin. Would really help with snacking and eating out when meal timing is unpredictable as well as faster corrections for highs. The corrections would be great. Ali

I would love it as well. I would imagine insulins that allow for shorter DIA's would help with glucose variability (standard deviation of BG's), and better control, and more flexibilty for snacking. I just hope it lives up to what it claims. The good news is that it's being worked on by the manufacturers of Novolog.

[Ellen]

Sounds great. It would take some work to manage it on a pump or even with injections because it is different but all the Dr.s/patients figured out how to tweak the insulins that have come along over the last fifty years. I remember those introductions and the adjustments to the new insulins. The pump background issue (if it really turned out to be one) could probably be easily dealt with by giving a bit of your basal via shot once a day similar to what people prone to ketones do now. I for one would love this insulin. Would really help with snacking and eating out when meal timing is unpredictable as well as faster corrections for highs. The corrections would be great. Ali

Many people I know used R or Velosulin in the pump when they first started before Humalog/Novolog/Apidra arrived.

[frizzyrazzy]

I think if rapid acting insulin changes significantly we're going to see pumps accommodate this by offering basal delivery differently - even smaller basal amounts would be my guess and more frequently than they do now.