Other Types Of Diabetes

[Denman]

Well I am currently diagnosed as, "Likely to be" type 1. But when I had my original tests, there was something unusual, aparently my GAD antibodies result came as negative which is not usual for those with type 1. So aparently I may have a rarer form of diabetes, and they have sent off new tests to a better lab.

Does anyone have any more info on this type of thing?

[muffins2]

hi, i think there is a type of diabetes like that, its called type 3. check it out

[BrendaK]

Only 80% of people with type 1 have the antibodies. 20% do not -- so you may indeed have type 1, just not the antibodies.

[lilituc]

I would guess they are thinking of MODY.

[Jackie UK]

Well I am currently diagnosed as, "Likely to be" type 1. But when I had my original tests, there was something unusual, aparently my GAD antibodies result came as negative which is not usual for those with type 1. So aparently I may have a rarer form of diabetes, and they have sent off new tests to a better lab.

Does anyone have any more info on this type of thing?

Hi

Here is some more information about the type of diabetes you may have. Though it is possible to have type 1 plus Mody. Let us know what happens

I have been in touch with a family where a child has type 1 plus mody.

" http://www.projects.ex.ac.uk/diabetesgenes/mody/info.htm

MODY runs in families because of a change in a single gene which is passed on by affected parents to their children. We call this Autosomal Dominant Inheritance. All children of an affected parent with MODY have a 50% chance of inheriting the affected gene and developing MODY themselves.


WHY IS IT IMPORTANT TO RECOGNISE IT?

There are different types of MODY. By finding out which type of MODY a person has the most appropriate treatment for them can be determined.

Knowing the type of MODY a person has also means we can advise them about how their diabetes will progress in the future.

As it runs in families, it is important to advise other family members of their risk of inheriting it.



WHAT DIFFERENT TYPES OF MODY HAVE BEEN IDENTIFIED?

MODY is caused by a change in a single gene. 6 genes have been identified that account for 87% of UK MODY:

HNF1-a

Glucokinase

HNF1-b (including Renal Cysts and Diabetes (RCAD))

HNF4-a

IPF1

Neuro D1


Changes in these different genes lead to different types of MODY. For more information about these different types of MODY please click on one of the above.

There are still more genes to identify as 13% of MODY is not yet accounted for.

Click here to download slides on diagnosing MODY

For further information on the clinical implications of a diagnosis of MODY, the following is a useful review:
Murphy R, Ellard S, Hattersley AT.
Clinical implications of a molecular genetic classification of monogenic beta-cell diabetes.
Nat Clin Pract Endocrinol Metab. 2008 Apr;4(4):200-13.


WHERE CAN I FIND OUT MORE INFORMATION?

For more information about MODY, please contact either :

Maggie Shepherd
01392 406772
M.H.Shepherd@exeter.ac.uk"




Jackie Jacombs